Last edited by Mek
Thursday, May 14, 2020 | History

4 edition of Inhibitors of cell growth found in the catalog.

Inhibitors of cell growth

  • 356 Want to read
  • 30 Currently reading

Published by Springer in Berlin, New York .
Written in English

    Subjects:
  • Cells -- Growth -- Regulation.,
  • Cancer cells -- Growth -- Regulation.,
  • Growth factors.,
  • Interferon.,
  • Oncogenes.,
  • Antioncogenes.

  • Edition Notes

    Includes bibliographical references and index.

    StatementAlvaro Macieira-Coelho (ed.).
    SeriesProgress in molecular and subcellular biology,, 20
    ContributionsMacieira-Coelho, Alvaro, 1932-
    Classifications
    LC ClassificationsOH506 .P76 no. 20, QH604.I53 .P76 no. 20
    The Physical Object
    Pagination272 p. :
    Number of Pages272
    ID Numbers
    Open LibraryOL352406M
    ISBN 103540640924
    LC Control Number98011893

    Angiogenesis inhibitors are unique cancer-fighting agents because they block the growth of blood vessels that support tumor growth rather than blocking the growth of tumor cells themselves.. Angiogenesis inhibitors interfere in several ways with various steps in blood vessel growth.   Commonly used cancer cell growth inhibitory drugs, such as doxorubicin,cis-platinum, and vinblastine, do not have PTPase inhibitory activity. Thus, Cpd 5, as a unique PTPase inhibitor and a potent cell growth inhibitor, may represent a novel class of cancer cell growth inhibitors.

    What are EGFR inhibitors?. Epidermal growth factor receptor (EGFR) inhibitors are a new group of medicines developed to treat a wide range of cancers. Overexpression of EGFR by about 30% of cancers is one reason for their excessive cell proliferation and tumour growth.. Although effective in the treatment of many cancers, EGFR inhibitors often result in adverse reactions in the skin, which. Thus, in order to inhibit cancer cell growth more effectively, activators, not inhibitors of PKM2, should be used. Activators of PKM2, such as N, N’-diarylsulfonamides, thieno-pyrrole-pyridazinones and tetrahydroquinolinesulfonamides, have been identified and studied through high throughput screening and SAR exploration [ - ].Cited by:

    A growing cancer cell divides in two: mTOR inhibitors such as everolimus help regulate cellular processes in cancer. The target of rapamycin (known as mTOR or the mechanistic target of rapamycin) is a protein that tells cells when to grow, divide, and survive. mTOR often mutates in cancer cells, leading to uncontrolled tumor cell growth. Autocrine cell growth inhibitors secreted into the culture medium are responsible for this effect. The objective of this investigation was the determination of components of conditioned medium which cause low growth rates and cell death. We found that other secreted inhibitors must exist than the metabolites ammonia and by: 6.


Share this book
You might also like
Israels attempt at economic stabilization

Israels attempt at economic stabilization

The joy of Calvinism

The joy of Calvinism

Australian Government today.

Australian Government today.

[Autograph letters written by Samuel Johnson, Boswell, Mrs. Piozzi, Mrs. Siddons and others, 1710-1823

[Autograph letters written by Samuel Johnson, Boswell, Mrs. Piozzi, Mrs. Siddons and others, 1710-1823

Enchanted isle

Enchanted isle

Atlas of primitive man in China

Atlas of primitive man in China

Organizing successful YMCA tournaments

Organizing successful YMCA tournaments

Acreage, yield, and production of field seed crops

Acreage, yield, and production of field seed crops

Elizabeth Marsland.

Elizabeth Marsland.

Healthy places - healthy people, healthy people - healthy places

Healthy places - healthy people, healthy people - healthy places

Regional houses, from a continuing series ..

Regional houses, from a continuing series ..

Save money, save gas

Save money, save gas

address, delivered before the Newburyport Mechanic Association at their anniversary meeting, Oct. 28, 1812

address, delivered before the Newburyport Mechanic Association at their anniversary meeting, Oct. 28, 1812

Inhibitors of cell growth Download PDF EPUB FB2

The containment of cell Inhibitors of cell growth book is at the core of the homeostatic regulation of metazoans, and considerable progress has been made Inhibitors of cell growth book the understanding of how this is achieved.

Most knowledge comes from the isolation of molecu­ les with positive and negative regulatory effects on cell proliferation, and most emphasis so far has been on these. This book covers the whole range of inhibitors of cell growth, and considers therapeutic applications, development and structure-function relationships.

Buy this book eB68 € price for Spain (gross) Buy eBook ISBN ISBN: OCLC Number: Description: pages: illustrations ; 25 cm. Contents: The growth-inhibitory effects of TGF₎ / R.E. Herrera --Big brothers are watching: the retinoblastoma family and growth control /P. Stiegler and A.

Giordano --The growth-regulatory role of p21(WAF1/CIP1) / A.L. Gartel and A.L. Tyner --Mechanisms of cell cycle blocks at the G2/M. The Growth-Regulatory Role of p21(WAF1/CIP1).- 1 Introduction.- 2 pInduced Growth Arrest Is Mediated Through Protein-Protein Interactions.- p21 Promotes Cell-Cycle Arrest via Interactions with Cdks and PCNA.- Proteins Other than Cdks and PCNA that Bind p Protein Interaction Domains of p 3 p21 Expression During Development Author: Alvaro Macieira-Coelho.

Kinase Inhibitor Drugs includes: A lineup of clinical-phase growth factor receptor inhibitors. Inhibitors of cell cycle kinases. I strongly recommend this book to anyone who is interested and new to the field of kinase inhibitors.

Indeed, I believe this book should not merely sit on the shelves of kinase experts, but should be used. The epidermal growth factor receptor (EGFR) family and the human EGFR 2 (HER2) of the receptor tyrosine kinases play essential roles in regulating cell proliferation, survival, and differentiation.

Because of their pivotal role in cellular function and growth, many inhibitors of EGFR and HER2 have been approved as targeted treatments for many.

Hormone - Hormone - Growth inhibitors: Growth inhibitors of various types have been identified in plants. The best characterized one is abscisic acid, which is chemically related to the cytokinins. It is probably universally distributed in higher plants and has a variety of actions; for example, it promotes abscission (leaf fall), the development of dormancy in buds, and the formation of.

William J. Chain, in Strategies and Tactics in Organic Synthesis, Abstract. Englerin A is a guaiane sesquiterpene with potent and selective growth inhibition activity against six human renal cancer cell lines. Englerin A has captured the attention of the synthetic organic chemistry community owing to its exciting activity and its attractive polycyclic and functionalized structure.

Get this from a library. Inhibitors of cell growth. [Alvaro Macieira-Coelho;] -- The study of the control of cell growth is of particular importance for the understanding of cancer and various developmental abnormalities.

This book considers both internal and external regulators. The four compounds inhibited prostate cancer PC-3 cell growth in a dose-dependent manner, whereas CG and MG inhibited breast cancer MDA-MB cell growth. All Cited by: Sigma offers several small molecules that inhibit a cell’s initiation of or progression through the apoptosis process.

This set of compounds includes inhibitors of c-Myc, Bax, p53, tBid, and BCL that mediate apoptosis as well as caspase inhibitors and other enzymes involved in the apoptotic pathways. Apoptosis inhibitors are important research tools when investigating the cellular mechanisms.

Growth factor receptor inhibitors (growth factor inhibitors, growth factor receptor blockers, growth factor blockers, growth factor receptor antagonists, growth factor antagonists) are drugs that target the growth factor receptors of cells.

They interfere with binding of the growth factor to the corresponding growth factor receptors, impeding cell growth and are used medically to treat cancer.

Platelet-derived growth factor (PDGF) regulates cell growth and development. Vascular endothelial growth factors (VEGFR) are involved in the creation of blood vessels. Tyrosine kinase inhibitors (TKIs) are a class of chemotherapy medications that inhibit, or block, the enzyme tyrosine kinase.

T-cell inhibitors help orchestrate the complexities of adaptive immunity. Dysregulation can lead to: increased T-cell activity, producing autoimmunity, hypersensitivity, and transplant rejection; or reduced tumor-specific T-cell activity producing malignant cell by: 1.

mTOR inhibitors are a class of drugs that inhibit the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs). mTOR regulates cellular metabolism, growth, and proliferation by forming and signaling through two protein complexes, mTORC1 and ical target: • FKBP12, • mTOR.

Inhibitors and activators are critical tools for researchers in the field of cell biology to obtain a comprehensive understanding of cell function, cell signaling and the intracellular mechanisms that control cell fate, function, and by: 3.

Mammalian target of rapamycin (mTOR) is a protein that regulates vital cell growth processes in a living organism. mTOR acts as a communication command centre in human body by receiving external signals from growth factors, hormones, proteins and transfer the signal to ON or OFF mode for the cell to grow and divide.

mTOR is considered as a member of the phosphatidylinositol 3-kinase (PI3K. pharmaceuticalsf Effect of GPD2 activity inhibitors on the growth of PC-3 and PNT1A cells. Normal and malignant prostate epithelial cell lines were cultured in the presence of 10 µM inhibitors for 72 h.

The data are displayed as % cell growth compared to untreated cells. The global PARP inhibitors market is primarily driven by increase in the rates of incidence and prevalence of cancer. In addition, increase in the adoption of PARP inhibitor drugs, growth of geriatric population, and advancements in the global health care sector are expected to boost the global PARP inhibitors market in the next few years/5(40).

A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma.

Eur Urol. ;71(6)– [67]Cited by: 1. The new plant growth inhibitors are derived from natural and artificial auxins but have a bulky benzoyl group - a chemical conjugate derived from benzoic acid - attached that prevents movement of the inhibitor out of the cell.

These results suggest that the splicing alterations and protein depletion of multiple factors for growth and survival contribute to the observed cellular effects of the CLK inhibitors in this cell line. Additionally, CLK inhibitors altered splicing patterns of AURKA, HDAC1, and PARP, all of which are critical factors of cell survival (Fig.

5A).Cited by: Cell Cycle Inhibitors. Cell cycle inhibitors slow or stop cell cycle progression through various mechanisms. Cell cycle arrest can be induced at different stages, decreasing the rate of cell division and the number of actively cycling cells. Products. Literature (2) Inhibitors; Cat.

No.